Kancera strengthens its patent portfolio in cancer metabolism

2011-12-23

Kancera report that the Company has registered a patent application for novel compounds targeting the energy metabolism of cancer. The new patent application covers a strategy to facilitate the uptake of substances in cancer cells. These synthetic molecules weaken the tumor by inhibiting the energy metabolism of cancer cells, thereby breaking the tumor resistance to radiation and chemotherapy, without harming healthy cells.
Kancera has been invited to present the project at the World Cancer Metabolism Summit, February 2012, in Washington, USA.

Kancera has previously reported that active substances against cancer energy metabolism significantly increase the sensitivity of cells derived from gastric cancer to cis-platin, a clinically proven chemotherapy that are widely used in the treatment of cancer. Kancera has during June and September 2011 registered two international patent applications (PCT/EP2011/060526 and PCT/EP2011/066250). The new patent application covers an additional new compound class of small synthetic molecules.

About PFKFB3 project
Blocking the mechanisms that enable cancer cells to overcome periods of hypoxia (oxygen defiency), may pave the way for new treatment strategies. The project is based on a specific inhibition of the enzyme PFKFB3 resulting in decreased metabolism and cell growth in hypoxic cancer environments.

Inhibition of PFKFB3 is expected to starve and weaken the tumor cells by reducing its glycolysis and cell division. In this way one can overcome the current problems with tumor resistance to radiation and chemotherapy.

About Kancera AB (publ)
Kancera develops small molecules starting with new treatment concepts and ending with a drug candidate. Kancera is currently running two projects, one to develop a treatment for leukemia and one project targeting cancer’s ability to generate energy in order to survive. Kancera also develops cancer models that allow the effect of the candidates to be studied before clinical trials are started. These models and techniques will be offered to third parties in order to further strengthen relations with the established industry and create future cost coverage for our own project development. Kancera’s operations are run at Pharmacia’s former premises at Kungsholmen in Stockholm. Kancera expects to employ around 20 people in 2011. The share is traded at NASDAQ OMX First North. The number of shareholders is approximately 1000. Remium AB is the Certified Adviser to Kancera.

For further information please contact:
Dr. Thomas Olin, VD, 46 (0)73-520 40 01

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